Strain

Background

Reference

C57BL/6

BALB/c

129×B6

Live

Embryo

MEF

Live

MEF

Live

TLR & adaptor

MyD88 KO

○

○

○

○

○

Adachi, O. et al., 1998. Immunity.

9: 143-150.

TLR1 KO

○

○

○

Takeuchi, O. et al., 2002. J Immunol. 169: 10-14.

TLR2 KO

○

○

○

○

○

Takeuchi, O. et al., 1999. Immunity.

11: 443-451.

TLR3 KO

○

○

○

○

○

Yamamoto, M. et al., 2003. Science. 301: 640-643.

TLR4 KO

○

○

○

○

○

Hoshino, K. et al., 1999. J Immunol. 162: 3749-3752.

TLR5 KO

○

○

○

Uematsu, S. et al., 2006. Nat Immunol. 7: 868-874.

TLR6 KO

○

○

○

Takeuchi, O. et al., 2001. Int Immunol. 13: 933-940.

TLR7 KO

○

○

○

○

○

Hemmi, H. et al., 2002. Nat Immunol.

3: 196-200.

TLR9 KO

○

○

○

○

○

Hemmi, H. et al., 2000. Nature.

408: 740-745.

TLR2/4

 double KO

○

○

○

－

TLR7/9

 double KO

○

○

○

－

TLR2/4/9

 Ｔｒｉｐｌｅ KO

○

○

○

－

TRIF KO

○

○

○

Yamamoto, M. et al., 2003. Science. 301: 640-643.

Myd88/TRIF

Double KO

○

○

○

－

TRAM KO

○

○

○

Yamamoto, M. et al., 2003. Nat Immunol. 7: 1144-1150.

TIRAP KO

○

○

○

Yamamoto, M. et al., 2002. Nature. 420: 324-329.

RLR family      *2 How to offer

RIG-I KO

○

Hiroki, K. et al., 2005. Immunity. 23: 19-28.

MDA5 KO

○

○

Hiroki, K. et al., 2006. Nature. 441: 101-105.

LGP2 KO

○

○

Takeshi, S. et al., 2010.PNAS. 107: 1512-1517.

Transcription & regulator

Floxed Stat3

 KO

○

○

○

Takeda, K. et al., 1998. J Immunol. 161: 4652-4660.

Takeda, K. et al., 1999. Immunity. 10: 39-49.

Others

mPGES1

○

○

Uematsu,S.et al.,2002. J Immunol.

168：5811-5816

○（embryo）university or non-profit organization only.

*1 129/SvJ x C57Bl/6 Mixed.

*2 Breeding pair (Heterozygous male and female) only.

*3 Available on production orders for MEF cell.

    MEF(Mouse Embryonic Fibroblast) cell.

H O M E

Service

TLR family Knockout mouse

Enamelin Mutant mouse

Transgenic Rat

Histamine receptor

KO mouse

Corporate introduction

Reference