Strain

Background

Reference

C57BL/6

BALB/c

Live

Embryo

Live

Embryo

MyD88 KO

○

○

○

Adachi, O. et al., 1998. Immunity.

9: 143-150.

TLR1 KO

○

○

Takeuchi, O. et al., 2002. J Immunol. 169: 10-14.

TLR2 KO

○

○

○

Takeuchi, O. et al., 1999. Immunity.

11: 443-451.

TLR3 KO

○

○

○

Yamamoto, M. et al., 2003. Science. 301: 640-643.

TLR4 KO

○

○

○

Hoshino, K. et al., 1999. J　Immunol. 162: 3749-3752.

TLR5 KO

○

○

Uematsu, S. et al., 2006. Nat Immunol. 7: 868-874.

TLR6 KO

○

○

Takeuchi, O. et al., 2001. Int Immunol. 13: 933-940.

TLR7 KO

○

○

○

Hemmi, H. et al., 2002. Nat Immunol.

3: 196-200.

TLR9 KO

○

○

○

Hemmi, H. et al., 2000. Nature.

408: 740-745.

TLR2/4 double KO

○

○

－

TLR7/9 double KO

○

○

－

TLR2/4/9 Ｔｒｉｐｌｅ KO

○

○

－

TRIF KO

○

○

Yamamoto, M. et al., 2003. Science. 301: 640-643.

Myd88/TRIF Double KO

○

○

－

TRAM KO

○

○

Yamamoto, M. et al., 2003. Nat Immunol. 7: 1144-1150.

TIRAP KO

○

○

Yamamoto, M. et al., 2002. Nature. 420: 324-329.

Floxed Stat3 KO

○

○

Takeda, K. et al., 1998. J Immunol. 161: 4652-4660.

Takeda, K. et al., 1999. Immunity. 10: 39-49.

mPGES1

○

Uematsu,S.et al.,2002. J Immunol.

168：5811-5816

H O M E

Service

TLR family Knockout mouse

Enamelin Mutant mouse

Transgenic Rat

Histamine receptor

KO mouse

Corporate introduction

Reference