Bailor

Shizuo Akira, M.D., Ph.D.

WPI Immunology Frontier Research Center, Osaka University,

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Distribution for a fee Guide Knockout mice

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OrientalBioService

TLR family Knockout mice

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photo:mouse(white)-OrientalBioServicephoto:Cells-OrientalBioServiceテキスト ボックス: Natural immunomechanism by TLR

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It is the knockout mice which made the indispensable molecule suffer a loss to the signal transfer to immune cells (neor and substitution).

> Download Pamphlet (PDF)   > TLR

In stock

Strain

Background

Reference

C57BL/6

BALB/c

Live

Embryo

MEF

Live

Sperm

MEF

TLR & adaptor

TLR1 KO

-

-

-

-

Takeuchi, O. et al., 2002. J Immunol. 169: 10-14.

TLR2 KO

-

Takeuchi, O. et al., 1999. Immunity.

11: 443-451.

TLR3 KO

-

-

-

Yamamoto, M. et al., 2003. Science. 301: 640-643.

TLR4 KO

-

-

Hoshino, K. et al., 1999. J Immunol. 162: 3749-3752.

TLR5 KO

-

-

-

-

Uematsu, S. et al., 2006. Nat Immunol. 7: 868-874.

TLR6 KO

-

-

-

-

Takeuchi, O. et al., 2001. Int Immunol. 13: 933-940.

TLR7 KO

-

-

-

Hemmi, H. et al., 2002. Nat Immunol.3: 196-200.

TLR9 KO

-

-

Hemmi, H. et al., 2000. Nature.

408: 740-745.

TLR2/4

 double KO

-

-

-

-

TLR7/9

 double KO

-

-

-

-

TLR2/4/9

 Triple KO

-

-

-

-

MyD88 KO

-

Adachi, O. et al., 1998. Immunity.

9: 143-150.

TRIF KO

-

-

-

-

Yamamoto, M. et al., 2003. Science. 301: 640-643.

Myd88/TRIF

Double KO

-

-

-

-

TRAM KO

-

-

-

-

Yamamoto, M. et al., 2003. Nat Immunol. 7: 1144-1150.

TIRAP KO

-

-

-

-

Yamamoto, M. et al., 2002. Nature. 420: 324-329.

Transcription regulator

Floxed

 Stat3 KO

-

-

-

-

-

Takeda, K. et al., 1998. J Immunol. 161: 4652-4660.

Takeda, K. et al., 1999. Immunity. 10: 39-49.

Others

mPGES1

-

-

-

-

Uematsu,S.et al.,2002. J Immunol.

1685811-5816

 

Strain

Background

Reference

129/SvJ × C57BL/6 (×ICR *1) Mixed

Live

Embryo

MEF

RLR & adaptor

RIG-I KO

-

Hiroki, K. et al., 2005. Immunity. 23: 19-28.

MDA5 KO

-

Hiroki, K. et al., 2006. Nature. 441: 101-105.

LGP2 KO

-

Takeshi, S. et al., 2010.PNAS. 107:

1512-1517.

*1 Only RIG-I KO will be 129xB6xICR.

*2 Available on production orders for MEF cell.

MEF(Mouse Embryonic Fibroblast) cell.

If you wish to mouse individual of from frozen embryo, please contact us.