Bailor

Shizuo Akira, M.D., Ph.D.

WPI Immunology Frontier Research Center, Osaka University,

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Distribution for a fee Guide Knockout mice

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OrientalBioService

TLR family Knockout mice

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photo:mouse(white)-OrientalBioServicephoto:Cells-OrientalBioServiceテキスト ボックス: Natural immunomechanism by TLR

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It is the knockout mice which made the indispensable molecule suffer a loss to the signal transfer to immune cells (neor and substitution).

> Download Pamphlet (PDF)   > TLR

In stock

Strain

Background

Reference

and

RRID (Background)

C57BL/6

BALB/c

Live

Embryo

MEF

Live

Sperm

MEF

TLR & adaptor

TLR1 KO

-

-

-

-

Takeuchi, O. et al., 2002. J Immunol. 169: 10-14.

 

IMSR_OBS:2

TLR2 KO

-

Takeuchi, O. et al., 1999. Immunity.

11: 443-451.

 

IMSR_OBS:3 (C57BL/6)

IMSR_OBS:9 (BALB/c)

TLR3 KO

-

-

-

Yamamoto, M. et al., 2003. Science. 301: 640-643.

 

IMSR_OBS:13 (C57BL/6)

IMSR_OBS:14 (BALB/c)

TLR4 KO

-

-

Hoshino, K. et al., 1999. J Immunol. 162: 3749-3752.

 

IMSR_OBS:4 (C57BL/6)

IMSR_OBS:10 (BALB/c)

TLR5 KO

-

-

-

-

Uematsu, S. et al., 2006. Nat Immunol. 7: 868-874.

 

IMSR_OBS:15 (C57BL/6)

TLR6 KO

-

-

-

-

Takeuchi, O. et al., 2001. Int Immunol. 13: 933-940.

 

IMSR_OBS:5 (C57BL/6)

TLR7 KO

-

-

-

Hemmi, H. et al., 2002. Nat Immunol.3: 196-200.

 

IMSR_OBS:6 (C57BL/6)

IMSR_OBS:11 (BALB/c)

TLR9 KO

-

-

Hemmi, H. et al., 2000. Nature.

408: 740-745.

 

IMSR_OBS:7 (C57BL/6)

IMSR_OBS:12 (BALB/c)

TLR2/4

 double KO

-

-

-

-

IMSR_OBS:19 (C57BL/6)

TLR7/9

 double KO

-

-

-

-

IMSR_OBS:20 (C57BL/6)

TLR2/4/9

 Triple KO

-

-

-

-

IMSR_OBS:21 (C57BL/6)

MyD88 KO

-

Adachi, O. et al., 1998. Immunity.

9: 143-150.

 

IMSR_OBS:1 (C57BL/6)

IMSR_OBS:8 (BALB/c)

TRIF KO

-

-

-

-

Yamamoto, M. et al., 2003. Science. 301: 640-643.

 

IMSR_OBS:16 (C57BL/6)

Myd88/TRIF

Double KO

-

-

-

-

IMSR_OBS:22 (C57BL/6)

TRAM KO

-

-

-

-

Yamamoto, M. et al., 2003. Nat Immunol. 7: 1144-1150.

 

IMSR_OBS:18 (C57BL/6)

TIRAP KO

-

-

-

-

Yamamoto, M. et al., 2002. Nature. 420: 324-329.

 

IMSR_OBS:17 (C57BL/6)

Transcription regulator

Floxed

 Stat3 KO

-

-

-

-

-

Takeda, K. et al., 1998. J Immunol. 161: 4652-4660.

Takeda, K. et al., 1999. Immunity. 10: 39-49.

 

IMSR_OBS:29 (C57BL/6)

Others

mPGES1

-

-

-

-

Uematsu,S.et al.,2002. J Immunol.

1685811-5816.

 

IMSR_OBS:26 (C57BL/6)

 

Strain

Background

Reference

and

RRID (Background)

129/SvJ × C57BL/6 (×ICR *1) Mixed

Live

Embryo

MEF

RLR & adaptor

RIG-I KO

-

Hiroki, K. et al., 2005. Immunity. 23: 19-28.

 

IMSR_OBS:24

MDA5 KO

-

Hiroki, K. et al., 2006. Nature. 441: 101-105.

 

IMSR_OBS:23

LGP2 KO

-

Takeshi, S. et al., 2010.PNAS. 107: 1512-1517.

 

IMSR_OBS:25

*1 Only RIG-I KO will be 129xB6xICR.

Available on production orders for MEF cell.

MEF(Mouse Embryonic Fibroblast) cell.

If you wish to mouse individual of from frozen embryo, please contact us.

IMSR (International Mouse Strain Resource) Online database of mouse resources.

RRID Research Resource Identifier) You can refer to detailed of the strain by RRID.